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The disease begins when a human host is bitten by an infected female black fly.
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Some people are bitten up to 10,000 times by the tiny black fly. |

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Humans acquire the disease while fulfilling their regular daily activities. |
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Activities near fast-moving rivers are especially risky. |

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Skin manifestations of the disease include the presence of nodules containing adult female and male worms.
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Adult worms in the nodules are clumped together.
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Microscopic larvae produced by the thousands by adult worms are the primary cause of the disease.
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A rash is the common first sign of the disease.
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Loss of pigment
in the legs develops soon after.
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Loss of elasticity of the skin causes this condition.
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Damage to the eye includes opacity of the lens and the destruction of the optic nerve.
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The disease eventually results in complete blindness.
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Three approaches to the control of riverblindness.
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The disease is widespread in the Congo.
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Mectizan is the current drug of choice in the fight against riverblindness.
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Merck will provide Mectizan as long as necessary to control and eliminate the disease worldwide.
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